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What is Clenbuterlene?
Clenbuterlene is central nervous system (CNS) stimulant. It is a specific agonist, stimulating the adrenergic beta 2 receptors. It is used in certain countries in a medical sense as a bronchodilator in the treatment of asthma mainly due to its long half life.
Athletes and bodybuilders use the drug due to its thermogenic and anti-catabolic effects. This is down to its ability to slightly increase the body's core temperature, thereby raising calorie (energy) expenditure. It is thought that a 1°F increase yields around a 5% increase in maintenance calories burned. Studies on livestock suggest that clenbuterlene also has anabolic properties. However, this seems not to be the case in humans, thought to be due to the fact that humans lack the abundance of beta 3 receptors which increase insulin production and sensitivity.
Clenbuterlene is dosed in micrograms (mcg/µg), most commonly in tablet form, though there are other forms of administration such as liquids, nasal sprays and injectables.
Clenbuterlene side effects: Side effects are dose dependant, though most users will find that most tend to drop with continual use. Caution is advised when employing the use of Clenbuterlene in conjunction with other adrenoceptor agonists as side effects are likely to be increasing. It is for this reason that it is generally not recommended to use ephedrine.
Common side effects of clenbuterlene include: Headaches Muscular tremors (especially hand shakes) Muscular cramps Nervousness Insomnia Sweating Increased appetite Nausea Palpitations Hypertension (high blood pressure)
In view of the above side effects, it is obvious to assume that anyone with cardiac issues and/or hypertension should not use a stimulant such as Clenbuterlene and caution must be observed by those already using similar compounds in the treatment of existing medical conditions. In addition, there is very little conclusive knowledge of the cardiac effects of supra-physiological dosages in humans.
Commonly used doses: It is well known that Clenbuterlene use results in rapid down-regulation of beta 2 receptors. This is due to the powerful stimulatory effect of the drug. It is therefore pointless to use clenbuterlene for long periods without a break. Some believe that a two day on, two day off dosing schedule will allow adequate potential for receptor up-regulation. A much better regime would be a two week on, two week off cycle. Maximum plasma levels are reached around 2-3 hours after oral administration and terminal half life at 34 hours.
Reducing dosage is recommended in an attempt to limit harsh side effects. Most commonly, a user will start by taking one 20mcg tablet on day 1, followed by an increase of one tablet on subsequent days. Subject to personal tolerance levels, a dosage of 140mcg (seven tabs) will be used by day 7, and this level should be maintained for the entire second week. It would be fruitless to exceed seven or eight tablets daily due to receptor over-saturation. There is no requirement to taper down.
For the next 'cycle' of clen (i.e. weeks 5 & 6), there is no requirement to taper up from one tablet as your tolerance level should now be known. As an example, if the user finished the first cycle of clen on 7 tabs, they could recommence at a slightly lower dose of 4 or 5, and taper up again from this level. Again though, the user should again limit their intake to 7 or 8 tabs daily.
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